Life Span of Reticulocytes in Paroxysmal Nocturnal Hemoglobinuria.
نویسندگان
چکیده
P REVIOUS OBSERVATIONS have demonstrated the shortened life span of the red cell in patients with paroxysmal nocturnal hemoglohinuria ( PNH ).1.2 Studies of the survival of homologous PNH red cells by the Ashby technic and of autologous PNH cells labeled with radioactive sodium chromate have demonstrated a short and biphasic red cell survival curve in the patient and normal recipient. This life span pattern has suggested that at least two cell populations exist. Recent observations have also indicated that erythrocyte acetylcholinesterase ( ACh ) is low in this disorder. The reticulocyte has a lower concentration of ACh and is more susceptible to hemolysis in acidified serum.3 This present study was designed to study the separate in vivo survival of young (reticulocyte-rich ) and old ( reticulocyte-poor ) red cells in PNH patients. The survival of reticulocytes from patients with pernicious anemia during the onset of remission was studied in a similar fashion. These comparisons provide data which suggest that the red cell lesion in PNH is heterogenously distributed.
منابع مشابه
The life-span of complement-sensitive and -insensitive red cells in paroxysmal nocturnal hemoglobinuria.
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عنوان ژورنال:
- Blood
دوره 25 شماره
صفحات -
تاریخ انتشار 1965